Which of the Following Prevents Supercoiling of Bacterial DNA

Question

Which of the following prevents supercoiling of bacterial DNA?
A) macrolides
B) quinolones
C) penicillins
D) cephalosporins

Accepted Answer

Quinolones such as ciprofloxacin and levofloxacin target DNA gyrase, which is necessary for bacterial DNA replication and prevents supercoiling of DNA. Macrolides (A), penicillins (C), and cephalosporins (D) target different components of bacterial cells and do not directly affect DNA supercoiling.