Self-Reactive T Cells are Eliminated During the Development of Tolerance

Question

Self-reactive T cells are eliminated during the development of tolerance in the immune system.

Accepted Answer

During the process of central tolerance in the thymus gland, self-reactive T cells that recognize self-antigens with high affinity are deleted or inactivated to prevent them from attacking the body's own tissues. This ensures that only T cells that are able to recognize and respond to foreign antigens are able to participate in the immune response.