Which of the Following is Involved in B Cell Selection

Question

Which of the following is involved in B cell selection and tolerance?
A) clonal anergy
B) clonal deletion
C) clonal anergy and deletion
D) allelic exclusion

Accepted Answer

Both clonal anergy and deletion are involved in B cell selection and tolerance. Clonal anergy refers to a state in which B cells are unable to respond to antigen stimulation and are rendered functionally inert. Clonal deletion, on the other hand, refers to the elimination of autoreactive B cells that recognize self-antigens. Therefore, the best choice would be C, which includes both clonal anergy and deletion. Allelic exclusion, although involved in B cell development, is not directly related to B cell selection and tolerance.