Once Replication of the Chromosome Has Begun, DnaA is Inactivated

Question

Once replication of the chromosome has begun, DnaA is inactivated
A) as a result of being blocked from oriC binding.
B) by increased expression of FtsZ.
C) as a result of increased binding to ATP.
D) by increased binding of DnaA-ATP to oriC.

Accepted Answer

Once replication of the chromosome has begun, DnaA is inactivated as a result of being blocked from oriC binding. This is because once replication starts, the remaining single-stranded DNA creates a region of hemimethylation, which prevents DnaA from binding to oriC.