What Enzyme Catalyzes the Cleavage of PIP₂

Question

What enzyme catalyzes the cleavage of PIP2?
A) phospholipase A
B) phospholipase C
C) phospholipase D
D) phospholipase P
E) None of the answers is correct.

Accepted Answer

Phospholipase C catalyzes the cleavage of PIP2 (phosphatidylinositol 4,5-bisphosphate) into diacylglycerol (DAG) and inositol trisphosphate (IP3).