Toxins with ADP Ribosyltransferase Activity Cause

Question

Toxins with ADP ribosyltransferase activity cause
A) membrane pore formation.
B) immune system activation.
C) proteolytic degradation of host proteins.
D) adenylate cyclase inhibition.
E) inhibition of elongation factor 2.

Accepted Answer

Toxins with ADP ribosyltransferase activity, such as diphtheria toxin and Pseudomonas exotoxin A, modify elongation factor 2 (EF-2) by ADP-ribosylation, thereby inhibiting its ability to participate in protein synthesis. This results in the inhibition of protein synthesis within the host cell, leading to cell death.