The secondary signal needed for TH0 helper cells to differentiate into either TH1 cells or TH2 cells is the cross-link between ________ (on TH0 helper cells) and ________ (on APC cell).
A) CD154; CD40 B) MHC I; B7 C) CD4; MHC II D) CD8; MHC I E) CD28; B7