Severe Combined Immunodeficiency is Most Commonly Caused By

Question

Severe combined immunodeficiency is most commonly caused by
A) chromosome 22 trisomy.
B) Y-linked inherited hypermetabolism.
C) X-linked inherited enzyme or receptor deficiency.
D) chromosome 7 deletion.
E) XXY inheritance.

Accepted Answer

Severe combined immunodeficiency (SCID) is most commonly caused by X-linked inherited enzyme or receptor deficiencies, particularly in genes that encode for the common cytokine receptor gamma chain (γc) or adenosine deaminase (ADA).