Replication of Herpes Viruses Requires All of the Following Elements

Question

Replication of herpes viruses requires all of the following elements EXCEPT
A) primase.
B) helicase.
C) single-strand DNA binding proteins.
D) ligase.
E) viral DNA polymerase.

Accepted Answer

Ligase is not required for replication of herpes viruses. Instead, herpes viruses use a protein called UL12 exonuclease to perform the functions of DNA polymerase and ligase. Primase, helicase, single-strand DNA binding proteins, and viral DNA polymerase are all required for replication of herpes viruses.