Which of the Following Viral Groups Has Been Successfully Utilized

Question

Which of the following viral groups has been successfully utilized as vector in gene therapy?
A) rhabdoviruses
B) parvoviruses
C) lentiviruses
D) orthomyxoviruses
E) bacteriophages

Accepted Answer

Lentiviruses, such as HIV, have been successfully used as vectors in gene therapy due to their ability to integrate their genetic material into the host cell’s genome, allowing for stable long-term expression of the therapeutic gene. Rhabdoviruses, parvoviruses, and orthomyxoviruses are not commonly used in gene therapy due to limitations in their genetic capacity and/or immunogenicity. Bacteriophages are primarily used in bacterial gene therapy, not in human gene therapy.