Question 3

(Multiple Choice)

Which of the following is FALSE regarding the establishment of lysogeny?


A) Lambda phage DNA integrates as a prophage in the host genome at the att site by site-specific recombination.
B) Rolling-circle replication generates multiple genomes in tandem, which are eventually cleaved by the enzyme terminase.
C) Production of the repressor CI by the integrated prophage prevents superinfection by other lambda phages.
D) A CI lambda repressor dimer binds to the major groove of a specific DNA sequence in the bacterial host, preventing the transcription of lytic promoters.
E) Once integrated in the host's DNA, gene expression from the prophage is limited to a few proteins, including the repressor C1.

Answer

B