How Does the AraC Regulatory Protein Turn on Transcription in the Presence

Question

How does the AraC regulatory protein turn on transcription in the presence of arabinose?
A) With the addition of arabinose, AraC no longer dimerizes and will form a large loop by binding to araO and aria, and thus can interact with RNA polymerase to permit transcription.
B) The dimer will form a large loop by binding to araO and aria, and thus can interact with RNA polymerase to permit transcription.
C) With the addition, AraC no longer dimerizes and thus can interact with RNA polymerase to permit transcription.
D) It becomes less flexible, so that a monomer can bind to araI1 and araI2 and interact with RNA polymerase to permit transcription.
E) It becomes more flexible, so that the dimer can bind to araI1 and araI2 and interact with RNA polymerase to permit transcription.

Accepted Answer

In the presence of arabinose, AraC becomes more flexible, allowing the dimer to bind to araI1 and araI2. This interaction facilitates the recruitment of RNA polymerase to the promoter, thereby initiating transcription.