Resistance to the protein synthesis antibiotics can be carried out by all of the following EXCEPT

A) the use of an acetyltransferase to destroy activity.
B) immediate metabolization to gain ATP.
C) efflux pumps to move it out of the cell.
D) the use of phosphotransferases to chemically modify the antibiotic.
E) mutations in genes for the bacterial target so antibiotics can no longer bind.