Most Bones of the Skeleton Develop by Endochondral Ossification

Question

Most bones of the skeleton develop by endochondral ossification.

Accepted Answer

Endochondral ossification is the process by which most bones of the skeleton, including long bones, develop. It involves the replacement of a cartilage model by bone tissue. However, some bones such as the skull and clavicle develop by intramembranous ossification, where bone tissue forms directly from mesenchymal cells without a cartilage model.