If the sex ratio in a population is significantly different from 50:50, then which of the following will always be true?

A) The population will enter the extinction vortex.
B) The genetic variation in the population will increase over time.
C) The genetic variation in the population will decrease over time.
D) The effective population size will be greater than the actual population size.
E) The effective population size will be less than the actual population size.