A few decades ago, Knudsen and colleagues proposed a theory that, for a normal cell to become a cancer cell, a minimum of two genetic changes had to occur in that cell. Knudsen was studying retinoblastoma, a childhood cancer of the eye. -Two children are born from the same parents. Child one inherits a predisposition to retinoblastoma (one of the mutations)and child two does not. However, both children develop the retinoblastoma. Which of the following would you expect?
A) an earlier age of onset in child one B) a history of exposure to mutagens in child one but not in child two C) a more severe cancer in child one D) increased levels of apoptosis in both children E) decreased levels of DNA repair in child one