The Activation of Receptor Tyrosine Kinases is Characterized By

Question

The activation of receptor tyrosine kinases is characterized by
A) dimerization and phosphorylation.
B) dimerization and IP₃ binding.
C) a phosphorylation cascade.
D) GTP hydrolysis.
E) channel protein shape change.

Accepted Answer

Activation of receptor tyrosine kinases involves the dimerization (coming together) of receptor monomers, followed by phosphorylation of tyrosine residues on their cytoplasmic tails by the kinase domains of their partner monomer. This leads to the activation of downstream signaling pathways.