Typically, Methylation of Nucleosome N- Terminal Tails Leads To_________

Question

Typically, methylation of nucleosome N- terminal tails leads to_________ .
A) tighter packaging of the chromatin and reduced transcription
B) relaxed packaging of the chromatin and increased transcription
C) removal of the protein components of the chromatin from the DNA
D) activation of topoisomerase
E) increased amounts of euchromatin relative to heterochromatin

Accepted Answer

Methylation of nucleosome N-terminal tails generally leads to tighter packaging of the chromatin, which in turn reduces transcription. This is because the compact structure limits the accessibility of DNA to transcription machinery.