Stretch Increases the Force of Cardiac Contraction Mainly By

Question

Stretch increases the force of cardiac contraction mainly by A) Increasing the size of the Ca²⁺ transient B) Increasing the sensitivity of the myofilaments for Ca²⁺ C) Increasing the turnover number of activated acto-myosin cross bridges D) Decreasing the jamming of the myofilaments at short lengths E) Increasing stretch of passive elements

Accepted Answer

Stretch increases the force of cardiac contraction mainly by increasing the sensitivity of the myofilaments for Ca²⁺, which is known as the Frank-Starling mechanism.