In the Lipid- Dissolution Model of Passive Transport, the Rate-

Question

In the lipid- dissolution model of passive transport, the rate- limiting step in the prrmeation is
A) Dissolution of the solute in the lipid phase on the source side of the membrane
B) Dissolution of the solute in the aqueous phase on the sink side of the membrane
C) Diffusion of the solute through the lipid interior of the membrane
D) Conformational changes in the carrier
E) The number of pores in the membrane.

Accepted Answer

The lipid-dissolution model of passive transport emphasizes that the rate-limiting step in the permeation of a solute is its diffusion through the lipid interior of the membrane. This is because the lipid bilayer acts as a barrier to the solute, and the rate at which the solute can cross this barrier by diffusing through the lipid phase is what ultimately determines the rate of transport across the membrane.