Turn Off of a Gs Mechanisms Requires

Question

Turn off of a Gs mechanisms requires
A) Activation of $\alpha$2receptors
B) degradation of cAMP by cAMP phosphodiesterase
C) PKA activation
D) Protein phosphatase inhibition
E) Protein phosphorylation

Accepted Answer

The turn off of a Gs mechanism, which is responsible for activating adenylate cyclase and increasing cAMP levels in the cell, requires the degradation of cAMP. This degradation is carried out by cAMP phosphodiesterase, which converts cAMP into AMP, thus terminating the signal transduction pathway initiated by Gs activation.