Pharmacom Echanical Coupling Develops Smooth Muscle Force By

Question

Pharmacom echanical coupling develops smooth muscle force by
A) Release of Ca2+ via G
B) Voltage-gated Ca2+ ch an ne ls a ctiv ate d b y ac tion po ten tials
C) Voltage-gated Ca2+ channels activated by mem brane potential change without action po ten tials
D) Ca2+ release through RyR
E) Ca2+ uptake into the SR m ediated by phospholamban phosphorylation

Accepted Answer

Pharmacomechanical coupling in smooth muscle involves the release of Ca₂+ via G-protein coupled receptors, which activate intracellular signaling pathways leading to Ca₂+ release from the sarcoplasmic reticulum without the need for membrane depolarization or action potentials.