Oral Hypoglycemic Agents Such as Tolbutamide and Glyburide

Question

Oral hypoglycemic agents such as tolbutamide and glyburide
A) Mimic insulin actions by increasing GLUT-4 in peripheral tissues
B) Increase insulin secretion by inhibiting the KATPchannel
C) Increase insulin action by sensitizing the insulin receptor
D) Phosphorylate IRS in target tissues
E) Bind to the sulfate receptor

Accepted Answer

Oral hypoglycemic agents like tolbutamide and glyburide are sulfonylureas that increase insulin secretion from pancreatic beta cells by inhibiting the potassium channel (specifically, the ATP-sensitive K+ channel, often abbreviated as KATP channel), leading to cell depolarization and insulin release.