W Hich of the Following is NOT an Effect of ACTH

Question

W hich of the following is NOT an effect of ACTH on adrenocortical cells?
A) ACTH increases cAMP in the adrenocortical cells
B) ACTH increases StAR that imports cholesterol into mitochondria
C) ACTH increases the receptor for LDL cholesterol
D) ACTH increases the enzymes for pregnenolone synthesis
E) ACTH increase enzymes for phospholipid breakdown

Accepted Answer

ACTH primarily stimulates the adrenal cortex to produce and secrete glucocorticoids, mineralocorticoids, and androgens. It does so by increasing cAMP, enhancing the expression of StAR (steroidogenic acute regulatory protein) for cholesterol transport into mitochondria, upregulating LDL cholesterol receptors, and boosting enzymes for pregnenolone synthesis. However, it does not directly increase enzymes for phospholipid breakdown; this process is not a recognized effect of ACTH on adrenocortical cells.