The Main Inhibition of ACTH Secretion is By

Question

The main inhibition of ACTH secretion is by
A) SST
B) Insulin
C) IGF-1
D) GLP-1
E) Glucocorticoids

Accepted Answer

The main inhibition of ACTH (Adrenocorticotropic Hormone) secretion is by glucocorticoids through a negative feedback mechanism. Glucocorticoids are steroid hormones produced by the adrenal cortex, and their release is stimulated by ACTH. When their levels are high, they inhibit further secretion of ACTH to maintain homeostasis.