What is the Difference Between SiRNA and ShRNA

Question

What is the difference between siRNA and shRNA?
A) siRNA is used for eukaryotes;shRNA is used for prokaryotes
B) siRNA is used for stable silencing;shRNA is used for transient silencing
C) siRNA is 50 nucleotides;shRNA 19-22 bp
D) siRNA is ssRNA;shRNA is dsRNA
E) siRNA is chemically synthesized;shRNA is delivered to the cell as a plasmid

Accepted Answer

SiRNA is often chemically synthesized and introduced into cells to knock down gene expression temporarily, while shRNA is typically expressed from a plasmid or viral vector for more stable gene silencing.