Which of the following would be most useful in a synthetic circuit to accelerate a screen for drugs that inhibit the activity of a negative transcription regulator,EthR,from Mycobacterium tuberculosis?

A) translational fusion of VP16 with a reporter gene
B) translational fusion of ethR with the VP16 transcriptional activator
C) translational fusion of ethR with a reporter gene
D) place VP16 under control of the cis-element to which EthR native binds promoter
E) place GFP under control of the cis-element to which EthR native binds promoter