What would be the consequences of a two nucleotide-deletion mutation in the middle of the first exon of a protein-coding gene?

A) The result would be no change in the protein, since deletions are very rare.
B) A reading frameshift would occur. All codons (and thus amino acids) downstream of the codon in which the deletion occurred would be different, including the stop signal.
C) Some codons might be altered since there are changes in the bases of the DNA, but the stop codon would remain the same and the protein would still be made.
D) Since exons are not coding regions, no changes in the protein would occur.
E) No change in the reading frame would occur due to the degeneracy of the genetic code.