Tay-Sachs is a Fatal Disease Caused by a Dysfunctional, Lysosomal

Question

Tay-Sachs is a fatal disease caused by a dysfunctional, lysosomal enzyme in the brain.

Accepted Answer

Tay-Sachs disease is caused by a deficiency of the enzyme hexosaminidase A, which leads to the accumulation of GM2 ganglioside in the brain, resulting in neurodegeneration.