In a segment of DNA, an A base is changed to a C and the error is copied during replication.Under which circumstances is that change considered a mutation? (Select all that apply. )

A)The change alters the phenotype of the organism's offspring.
B)The change results in production of a novel protein.
C)The change is in a somatic cell, such as a skin cell.
D)The change is in a gene, but has no effect on a gene product or phenotype.