What is One Problem Associated with Using Retroviruses as Human

Question

What is one problem associated with using retroviruses as human gene therapy vectors?
A)Their random integration into the host chromosome may result in detrimental mutations.
B)They need to integrate through an RNA intermediate.
C)The level of proteins produced from them is usually very low.
D)The level of proteins produced from them is usually very high.

Accepted Answer

Retroviruses integrate their genetic material into the host genome at random locations, which can disrupt normal gene function or activate oncogenes, potentially leading to detrimental mutations or cancer.