How Do Large Polar and Charged Molecules Cross Biological Membranes

Question

How do large polar and charged molecules cross biological membranes?
A)Large polar and charged molecules can't cross biological membranes.
B)Large polar and charged molecules cross biological membranes via diffusion through the hydrophilic core of the membrane.
C)Large polar and charged molecules must be hydrolyzed before they can cross a biological membrane.
D)Large polar and charged molecules cross biological membranes via transport proteins that form hydrophilic channels through the membrane.
E)Both A and C

Accepted Answer

Large polar and charged molecules cannot easily cross the hydrophobic core of biological membranes due to their polarity and charge. They typically require transport proteins, which provide a hydrophilic path through the membrane, to facilitate their movement across.