In Eukaryotes,the 3ʹ End of the MRNA is Important in the Initiation

Question

In eukaryotes,the 3ʹ end of the mRNA is important in the initiation of translation because
A)it contains Kozak sequences that aid in initiation.
B)translation occurs in the 3ʹ to 5ʹ direction.
C)eIF4A is attached to the 3ʹ end and removes any secondary structure that might prevent translation.
D)the 3ʹ poly(A)tail and PABP bind initiation factor eIF4G,stabilizing the 5ʹ end of the mRNA.
E)it contains Kozak sequences that aid in initiation of translation in the 3ʹ to 5ʹ direction.

Accepted Answer

The 3ʹ poly(A) tail and Poly(A) Binding Protein (PABP) interact with the initiation factor eIF4G, which helps to stabilize the 5ʹ cap structure of the mRNA. This interaction is crucial for the initiation of translation in eukaryotes, as it facilitates the recruitment of the ribosome to the mRNA.