Which of the following statements about CRISPR are accurate? Select all that apply.

A)CRISPR was first discovered in single-celled eukaryotes.
B)Where naturally found in cells,CRISPR acts as a form of immune defense against viruses.
C)CRISPR utilizes an endonuclease enzyme called Cas9.
D)CRISPR can only be used by researchers to target a specific sequence of nucleotides in single-celled prokaryotes and eukaryotes.
E)CRISPR requires a guide RNA molecule to identify the nucleotide sequence destined for editing.