Which of the Following Statements About Integrins is FALSE

Question

Which of the following statements about integrins is FALSE?
A)Integrins use adaptor proteins to interact with the microtubule cytoskeleton.
B)Integrins can switch to an activated state by binding to an extracellular matrix molecule.
C)Integrins can switch to an activated state by binding to an intracellular protein.
D)An activated integrin molecule takes on an extended conformation.

Accepted Answer

Integrins use adaptor proteins to interact with the cytoskeleton, but specifically the actin cytoskeleton. They can switch to an activated state by binding to extracellular matrix molecules or intracellular proteins. In an activated state, the integrin molecule undergoes a conformational change that exposes binding sites for other molecules.