An Inactivating Mutation in the Progesterone Receptor Gene Would Likely

Question

An inactivating mutation in the progesterone receptor gene would likely result in
A) the inability of the uterus to support pregnancy.
B) the absence of pituitary gonadotropin hormones.
C) the absence of secondary sex characteristics.
D) the absence of mammary gland development.
E) enlarged and hyperactive uterine endometrium.

Accepted Answer

The progesterone receptor plays a key role in regulating the growth and function of the uterus during the menstrual cycle and pregnancy. An inactivating mutation in this gene would result in the inability of the uterus to respond to progesterone, which is necessary for the establishment and maintenance of pregnancy. As a result, the uterus would not be able to support pregnancy.