Lentiviral Vectors are Preferred Over Adenoviral Vectors Because_______

Question

Lentiviral vectors are preferred over adenoviral vectors because_______ .
A)the lentivirus cannot infect nondividing cells
B)they do not have to be engineered by taking out their replicative genes
C)the inserted DNA forms episomes,which prevent insertion mutations
D)the inserted DNA cannot be reproduced when cells divide

Accepted Answer

Lentiviral vectors are preferred because the inserted DNA forms episomes, which do not integrate into the host genome, thereby reducing the risk of insertional mutagenesis. This is a significant advantage over other viral vectors that integrate into the host genome, which can disrupt host genes and potentially lead to cancer.