Which of the Following Can Contribute to the Initiation of Cancer

Question

Which of the following can contribute to the initiation of cancer?
A)Somatic mutations
B)Germ-line mutations
C)Gene amplification
D)Aneuploidy
E)All of the above

Accepted Answer

All of the listed factors can contribute to the initiation of cancer. Somatic mutations occur in non-reproductive cells and can accumulate over time, leading to gene alterations that promote cancer development. Germ-line mutations are present in all cells of an individual and can increase the risk of cancer development. Gene amplification, or an increase in the number of copies of a particular gene, can lead to overexpression of that gene and contribute to cancer development. Aneuploidy, or an abnormal number of chromosomes, can also promote cancer development by disrupting normal cell division and regulation.