Which of the Following is NOT True of β-Catenin

Question

Which of the following is NOT true of β-catenin?
A)It binds directly to the Wnt protein.
B)It associates with Tcf/Lef transcription factors in the nucleus,driving cell proliferation.
C)It can be degraded when bound to active GSK-3β.
D)It exists in a soluble pool in the cytosol.
E)None of the above.

Accepted Answer

β-catenin does not bind directly to the Wnt protein. Instead, Wnt signaling inhibits the degradation of β-catenin, allowing it to accumulate and enter the nucleus where it can influence gene expression by associating with Tcf/Lef transcription factors.