You are studying cancer cells,and hypothesize that you have found a previously unidentified tumor suppressor gene.Which of the following results would support your hypothesis?

A)You have found loss of heterozygosity in the locus containing your gene in a number of human lung cancer samples.
B)You have identified a gain-of-function mutation in this gene that results in the transformation of normal cells.
C)Functional analysis has revealed that the wild-type form of the gene that you have identified serves to drive proliferation.
D)B and C.
E)None of the above.