Which of the Following Types of Alterations Would NOT Promote

Question

Which of the following types of alterations would NOT promote tumorigenesis?
A)Overexpression of MDM2
B)Overexpression of Bak
C)Overexpression of Bcl-2
D)Defective Chk2 kinase signaling
E)Increased activation of PI3K

Accepted Answer

Overexpression of Bak, a pro-apoptotic protein, would not promote tumorigenesis. In fact, it would likely have the opposite effect by inducing apoptosis in cancer cells. The other options listed are alterations that have been associated with promoting tumorigenesis.