Increased Expression of MDM2 May Result In

Question

Increased expression of MDM2 may result in
A)Increased expression of p53.
B)Apoptosis.
C)Cell cycle arrest.
D)Degradation of p53.
E)Senescence.

Accepted Answer

MDM2 is a negative regulator of p53 and promotes its degradation. Increased expression of MDM2 would result in increased degradation of p53, leading to decreased cell cycle arrest, apoptosis, and senescence.