Which of the Following is NOT True of P53

Question

Which of the following is NOT true of p53?
A)Most tumor-associated p53 mutations are the result of nonsense codons.
B)p53 is mutated in over 30-50% of all cancers.
C)Normal p53 functions as a "tumor suppressor."
D)Mice lacking p53 are viable.
E)Exposure to UV radiation results in increased expression of p53.

Accepted Answer

Most tumor-associated p53 mutations are missense mutations or deletions/insertions. Nonsense codons may result in truncated, nonfunctional p53 protein, but they are not the most common mutation type.