Therapeutic Antibodies Used in the Treatment of Cancer are Targeted

Question

Therapeutic antibodies used in the treatment of cancer are targeted at proteins located
A)On the cell surface of cancer cells.
B)On the cell surface of normal cells.
C)In the nucleus of cancer cells.
D)In the cytoplasm of cancer cells.
E)C and D.

Accepted Answer

Therapeutic antibodies used in the treatment of cancer are designed to target proteins that are overexpressed or mutated on the surface of cancer cells. Targeting proteins on normal cells can result in off-target effects and toxicity, so antibodies are specifically designed to avoid normal cells. Proteins located in the nucleus or cytoplasm are not typically targeted by therapeutic antibodies as they are not accessible to the antibodies.