How has the treatment of mycobacterial disease changed in light of the multidrug-resistant strains of mycobacteria that are being isolated?

A) Antimicrobial therapy is started sooner in the course of the disease.
B) More powerful antimicrobial agents are used to treat mycobacterial disease.
C) Combinations of three or four drugs are used instead of a single drug.
D) Patients are hospitalized for the duration of their disease.