Progesterone Has a Negative-Feedback Effect on GnRH and LH

Question

Progesterone has a negative-feedback effect on GnRH and LH.

Accepted Answer

Progesterone inhibits the production of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), thus exerting a negative feedback effect on the hypothalamus and pituitary gland. This helps to prevent ovulation during pregnancy and maintain the uterine lining.