Is antigenic shift alone likely to lead to influenza pandemics? A.Yes-ONLY antigenic shift can lead to the large-scale mixing of gene elements required to produce a pandemic flu strain. B.No-ONLY antigenic DRIFT can lead to the large-scale mixing of gene elements required to produce a pandemic flu strain. C.Perhaps-but it would most likely be a mixture of antigenic shift AND drift that would result in a pandemic strain. D.No-antigenic SHIFT is responsible for changes in the hemagglutinin protein, while antigenic DRIFT is responsible for changes in the neuraminidase protein.You must have changes in both to lead to a pandemic strain.