Explain why HIV becomes resistant so quickly when a single drug is used therapeutically.
A.The virus is an RNA genome virus-by using host RNA polymerase to directly copy the genome to make more virus particles, there's no proofreading capability.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.
B.HIV utilizes reverse transcriptase to make a cDNA version of its RNA genome.This polymerase is 'sloppy,' with a high rate of error and lack of a proofreading capability.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.
C.HIV synthesizes a protein enzyme that directly cleaves anti-HIV drugs, giving it a characteristically high rate of resistance to a single drug type.
D.HIV is constantly changing its genetic structure by swapping genetic elements with other virus strains.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.