Sulfonamides Work As

Question

Sulfonamides work as
A)competitive inhibitors.
B)noncompetitive inhibitors.
C)ribosome-binding molecules.
D)feedback inhibitors.

Accepted Answer

Sulfonamides are competitive inhibitors that compete with para-aminobenzoic acid (PABA) for the active site on the enzyme dihydropteroate synthase (DHPS), which is responsible for the biosynthesis of folate in bacteria. This inhibits the bacterial folate pathway and ultimately leads to inhibition of DNA and RNA synthesis, preventing bacterial growth and replication.