Malignant hyperthermia is a hereditary disorder that can increase surgical risk because temperature may be elevated during certain types of anesthesia.The cause of the increased temperature is an increase in cytosolic Ca⁺⁺ level as a result of an anesthetic-induced:

A)Increase in Ca⁺⁺ release from the SR,as a result of a mutation in the ryanodine receptor.
B)Decrease in Ca⁺⁺ uptake by the SR,as a result of a mutation in SERCA.
C)Increase in frequency of the rupturing of skeletal muscle fibers.
D)Decrease in Ca⁺⁺ extrusion,as a result of hyperphosphorylation of the plasmalemmal Ca⁺⁺ pump.
E)Increase in Ca⁺⁺ influx,as a result of a mutation in N-type Ca⁺⁺ channels.